<

... aus dem Jahre 2012

Eine unendliche Geschichte

Alkohol -Ja ?      Alkohol -Nein ?

Rotwein?
Weißwein?
Überhaupt keinen Wein?
Oder Wein nur, wenn man auch Sport dazu treibt?
"Alles ist möglich!/ Nichts ist möglich!/
Alles ist unmöglich!/ Nichts ist unmöglich!"

Eine bereits ältere Variante aus dem Jahr 2012 finden Sie im
Bratislava Medical Journal Vol.113, No.3, p.156-158, 2012
unter dem Titel
A pilot randomized trial comparing long-term effects of red and white wines on biomarkers of atherosclerosis (In vino veritas: IVV trial)
  Author: M. Taborsky, P. Ostadal, M. Petrek
Abstract: Background: Since early 90', growing body of evidence indicates that the Mediterranean diet with mild to moderate consumption of wine, mostly red wine, has a protective effect on cardiovascular diseases. Several mechanisms have been discussed to participate in the beneficial effect of red wine, such as antioxidant or vasodilating activity. However, later it has been shown that also other alcoholic beverages have a protective effect on atherosclerosis. Up to now, data from the prospective, long-term, head-to-head comparisons of the effects of different drinks on markers of atherosclerosis are insufficient. Methods: The IVV (in vino veritas) study is a long-term, prospective, multicenter, randomized trial comparing the effect of red and white wines on the markers of atherosclerosis. One hundred and twenty healthy subjects with mild to moderate risk of atherosclerosis will be randomized to regular consumption of red wine (Pinot Noir) or white wine (Chardonnay-Pinot) for one year. The primary endpoint is the level of HDL-cholesterol at one year, while secondary endpoints are levels of other markers of atherosclerosis (LDL-cholesterol, C-reactive protein, myeloperoxidase, advanced oxidation protein product, interleukins 6 and 18, matrix metalloproteinases, glutathione s-transferase, monocyte chemoattractant protein 1, soluble CD40L). Conclusion: The IVV trial is the first study focusing on the long-term prospective comparison of the effects of red and white wines consumption on HDL-cholesterol and other markers of atherosclerosis. Results of the IVV trial may extend our understanding of the widely discussed "French paradox" (Tab. 1, Ref. 21)

Keywords: red wine, white wine, atherosclerosis, HDL-cholesterol.
Year: 2012, Volume: 113, Issue: 3   Page 156 - 158
doi:10.4149/BLL_2012_037

und alles etwas lustiger dargestellt unter
http://www.scinexx.de/wissen-aktuell-17962-2014-09-01.html
und
http://www.scinexx.de/wissen-aktuell-17548-2014-05-13.html

Na, dann Prost (- oder auch nicht).

Für Sie gelesen am 5.August 2014

 

Association between alcohol and cardiovascular disease:

Medelian randomisation analysis based on individual participant data

--------------------------------------------

 
                                   Alkohol oder nicht Alkohol? - Das ist die Frage
              Am Anfang war es "ein Gläschen in Ehren", das niemand verwehren konnte.
              Es folgte das Rotwein-Paradoxon, aber nur bei französischen Rotweinen,
               - was die Italiener mächtig erzürnte- ,
              dann waren es die Polyphenole,
              dann der Alkohol an sich, (aber natürlich nur in "kleinen" Mengen)

- und jetzt kommt ein Allel der Alkoholdehydrogenase daher als AD1Brs1229984
und verdirbt den Genuss .
 
Conclusions: Individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health. 

 

Ob das wirklich akzeptiert wird?    Genügend Autoren sind ja beteiligt.
Aber lesen Sie selbst unter
http://www.bmj.com/content/349/bmj.g4164

einen Tag später (6.August 2014)

 

Es regt sich Widerstand unter http://www.bmj.com/content/349/bmj.g4334

Auch Medscape Deutschland hat diesen Artikel entdeckt:                                                                        http://www.medscapemedizin.de/artikel/4902467?src=wnl_medpl_04002014                                           Dort finden sich ebenfalls Kommentare.

 

im Internet gefunden

.... unendliche Geschichte ....
Anfang September 2014 habe ich die beiden nachfolgenden Arbeiten im Internet gefunden. (P.Bottermann)

März 2014

 

Alcohol and Cardiovascular Health: The Dose Makes the Poison or the Remedy

Mayo Clinic Proceedings

Volume 89, Issue 3, Pages 382 393, March 2014

Abstract

Habitual light to moderate alcohol intake (up to 1 drink per day for women and 1 or 2 drinks per day for men) is associated with decreased risks for total mortality, coronary artery disease, diabetes mellitus, congestive heart failure, and stroke. However, higher levels of alcohol consumption are associated with increased cardiovascular risk. Indeed, behind only smoking and obesity, excessive alcohol consumption is the third leading cause of premature death in the United States. Heavy alcohol use (1) is one of the most common causes of reversible hypertension, (2) accounts for about one-third of all cases of nonischemic dilated cardiomyopathy, (3) is a frequent cause of atrial fibrillation, and (4) markedly increases risks of stroke both ischemic and hemorrhagic. The risk-to-benefit ratio of drinking appears higher in younger individuals, who also have higher rates of excessive or binge drinking and more frequently have adverse consequences of acute intoxication (for example, accidents, violence, and social strife). In fact, among males aged 15 to 59 years, alcohol abuse is the leading risk factor for premature death. Of the various drinking patterns, daily low- to moderate-dose alcohol intake, ideally red wine before or during the evening meal, is associated with the strongest reduction in adverse cardiovascular outcomes. Health care professionals should not recommend alcohol to nondrinkers because of the paucity of randomized outcome data and the potential for problem drinking even among individuals at apparently low risk. The findings in this review were based on a literature search of PubMed for the 15-year period 1997 through 2012 using the search terms alcohol, ethanol, cardiovascular disease, coronary artery disease, heart failure, hypertension, stroke, and mortality. Studies were considered if they were deemed to be of high quality, objective, and methodologically sound.

Abbreviations and Acronyms:

AF (atrial fibrillation), BP (blood pressure), CAC (coronary artery calcium), CAD (coronary artery disease), CV (cardiovascular), DM (diabetes mellitus), HDL (high-density lipoprotein), HF (heart failure), HTN (hypertension), MI (myocardial infarction)

Die Originalarbeit finden Sie unter http://www.mayoclinicproceedings.org/article/S0025-6196(13)01002-1/fulltext

----------------------------------------------------------------------------------------

September 2014

 
 Association Between Alcohol Consumption and Risk of Cardiovascular Disease and All-Cause Mortality in Patients With Hypertension: A Meta-Analysis of Prospective Cohort Studies

Mayo Clinic Proceedings

Volume 89, Issue 9, Pages 1201 1210, September 2014

Abstract

Objective

To conduct a meta-analysis summarizing the risk of cardiovascular disease (CVD) and all-cause mortality (ACM) in relation to alcohol consumption in patients with hypertension, focusing on clarifying dose-response associations.

Patients and Methods

PubMed and EMBASE were searched for eligible prospective cohort studies from December 3, 1949, through January 18, 2014. The semi-parameter method and dose-response analysis were used.

Results

Nine studies (11 cohorts) were included in the meta-analysis. Compared with the lowest alcohol level (abstainers/occasional drinkers), the pooled relative risk (RR) was 0.72 (95% CI, 0.68-0.77) for the third highest category (median, 10 g/d), 0.81 (95% CI, 0.71-0.93) for the second highest category (median, 20 g/d), and 0.60 (95% CI, 0.54-0.67) for the highest category (median, 30 g/d). A J-shaped relationship between alcohol use and ACM was observed, and the nadir (RR, 0.82; 95% CI, 0.76-0.88) was found to be at a dose of 8 to 10 g of alcohol consumption per day.

Conclusion

Findings of this meta-analysis suggest that low-to-moderate alcohol consumption was inversely significantly associated with the risk of CVD and ACM in patients with hypertension.

Die Originalarbeit finden Sie unter http://www.mayoclinicproceedings.org/article/S0025-6196(14)005151/fulltext    

------------------------------------------------------------------------------------------------------  

jetzt reicht es --- endlich Schluss damit

Da die unendliche Geschichte “Alkohol ja - Alkohol nein” unendlich langweilig zu werden droht, soll mit dem nachfolgenden Artikel mit der unendlichen Geschichte, jedenfalls hier unter
gehört – gelesen, endlich Schluss sein.

(13.September 2014 - P.Bottermann)

More Bad Booze News: Even Moderate Drinking Linked With AF

Michael O'Riordan

July 14, 2014
12 comments

Alcohol Intake, Least CVD: Novel Study Busts U-Curve

Alcohol May Trigger AF Episodes

Topic Alert
Receive an email from Medscape whenever new articles on this topic are available.Add Atrial Fibrillation to My Topic Alert Drug & Reference InformationAtrial FibrillationHoliday Heart Syndrome

Pediatric Ventricular Fibrillation

STOCKHOLM, SWEDEN — Drinking alcohol, even light to moderate consumption, appears to be associated with an increased risk of developing atrial fibrillation, according to a new analysis[1].

Among individuals who drank between 15 and 21 drinks per week and those who drank more than 21 drinks in a week, the risk of atrial fibrillation was increased 14% and 39%, respectively, when compared with nondrinkers. Binge drinking, defined as having five or more drinks on any one occasion, was associated with a 13% higher risk of developing atrial fibrillation regardless of how many drinks were consumed in the week.

The risk of atrial fibrillation was also increased among those who consumed just one to two drinks per day, or seven to 14 drinks per week. Among those who drank lightly and who had no coronary heart disease or heart failure at baseline, the risk of atrial fibrillation was increased 12% compared with nondrinkers. However, in the entire cohort, which included those with baseline heart disease, the risk of atrial fibrillation was not elevated among the light drinkers.

"We know that heavy alcohol consumption increases the risk of atrial fibrillation," lead investigator Dr Susanna Larsson (Karolinska Institutet, Stockholm, Sweden) told heartwire . "There are also studies showing that moderate consumption increases the risk, but what's new here is that this is quite a small amount of alcohol [consumed], and the risk is also increased."

Prospective Study plus Meta-Analysis

The study, published online July 14, 2014 in the Journal of the American College of Cardiology, included 79 019 men and women who completed a questionnaire about alcohol consumption as part of the Cohort of Swedish Men (COSM) and Swedish Mammography Cohort (SWM) studies. After 12 years of follow-up, there were 7245 incident cases of atrial fibrillation.

Alcohol Drinking Status and Risk of Atrial Fibrillation

Fortsetzung

In addition to light and moderate alcohol consumption, the risk of atrial fibrillation was also observed among those who drank heavily. The relationship between alcohol consumption and atrial fibrillation remained even after excluding patients who were identified as binge drinkers. When stratified by the type of alcohol consumed, the relationship with atrial fibrillation was strongest for those who drank liquor, weaker for those who drank wine, and weakest for those who drank beer.

In addition to the COSM and SWM analysis, the researchers also conducted a meta-analysis. Combining COSM and SWM with five additional studies, the researchers "observed a linear dose-response relationship between alcohol consumption and atrial-fibrillation risk, with no evidence of departure from linearity."

In an editorial[2], Dr David Conen (University Hospital, Basel, Switzerland) and Dr Christine Albert (Brigham and Women's Hospital, Boston, MA) say the meta-analysis, which is in line with the prospective data, enhances their "confidence in the potential causality of the link between alcohol intake and atrial fibrillation."

The editorialists point out that hypertension and obesity are two important risk factors that explain about 40% of the population-attributable risk for atrial fibrillation, but there is no explanation for the remaining 50% or 60%.

"In comparison, modifiable risk factors explain 80% to 90% of the attributable risk for sudden cardiac death and MI, respectively," they write. "The present study supports the widely held contention that significantly elevated alcohol consumption, particularly binge drinking, is related to atrial fibrillation and should be avoided. The study also agrees with other prospective data suggesting that chronic levels of alcohol intake above two drinks per day may modestly elevate atrial fibrillation in men and women."

Although there is a weak association with even less amounts of alcohol, this study does definitively answer how much alcohol is too much, write Conen and Albert.

Neither the paper's authors nor the editorialists have any conflicts of interest.

References

Comments

Commenting is moderated. See our Terms of Use.
19 comments
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Dr. David Hodgson|  General Practice 40 spec 109 hours ago
I heartily concur with the sentiments and implied advice expressed in this article.My experience is that a regular but modest alcohol intake can be acceptable but binge-drinking can lead to AD.

David Hodgson MB, VS, DARCS.

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Dr. andre pessanha|  Cardiology, Interventional 285 spec 10Aug 20, 2014
Is that what i understood? A doctor defending alcohol consumption despite medical evidence against it? Amazing!

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Dr. Roger Rampling|  Psychiatry/Mental Health 61 spec 10Jul 19, 2014
It's the magnesium, stupid !

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emmanuel pippos|  Pharmacist 8 prof 8Jul 18, 2014
Thank you Dr. Silverstein. Alcohol induces oxidative stress in 70% of body tissues and cells because it is highly miscible (dissolves completely) with water. Trials are not necessary to discover anything new about the oxidative damage caused by alcohol in the body. By the way, it is essential to refer to alcohol by its correct name, ETHANOL. You know, it is a funny thing. Why do petrol companies not use the word "alcohol" for ethanol based fuel? 

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Terry Petty|  Other Healthcare Provider 15 prof 15Jul 18, 2014
On the last point, I find it hard to accept that any of the events you mentioned are denied their full measure of pleasure without the addition of alcohol. That hot summer evening or post cycling celebration is enjoyed simply, and perhaps more poignantly, without the mind altering effects of alcohol. The Buddhist notion of "renunciation" is not about disciplining oneself in a punishing way. It is about refraining from those things which impede our full participation in and enjoyment of what we are experiencing. It is not about sacrifice. It is about full appreciation of what is true and real.

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Joerg Pirl|  Other Healthcare Provider 15 prof 15Jul 17, 2014
From a toxicologist:  Alcohol is a natural constituent of our body - fermentation of carbohydrates in the gut, especially when a lot of fruit products are consumed.  Usually that concentration is less than 10mg/100mL of whole blood.  Studies I have participated in:  One to two standard drinks per day, type is of no consequences, reduces blood sugar in type II diabetes.  3 or more drinks at one time raises blood sugar dramatically.  Most reasonable cause; hepatoxicity by alcohol. As a side bar:  The report from Sweden was based on self reported data.  Those who consume distilled products frequently under estimate the quantity they consume.  One standard drink is equivalent to 1.25 oz of a 40% (V/V) alcohol product or 12 oz of 4.2% beer or 5.5 oz of 9% wine.  Red wine contains more alcohol.  Beer in Europe often contains more than 5% alcohol.  

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Dr. John Carroll|  Cardiology, General 32 spec 10Jul 17, 2014
John Mandrola is my kind of guy and doctor!

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Dr. Muttathil Ravindra Nathan|  Cardiology, General 32 spec 10Jul 17, 2014
Excellent article. Thanks





Dr M P R Nathan

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Yuri Blok|  Other Healthcare Provider 15 prof 15Jul 16, 2014
Moderateness was always considered as one of the greatest human virtues.

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Dr. GEORGE RITTER|  Cardiology, General 32 spec 10Jul 16, 2014
I cannot  believe so much time  and energy are being spent on such a poorly studied subject. Firstly, we all recognize  that people sensitivity  to  alcohol  is well known. Secondly. to depend upon self  reporting alcohol is a fools  game ,Thirdly, wine  and  beer as well as  many whiskeys  have all  kinds of  poorly studied additives that will  have to  be accounted  for. Lets just stop all this money wasting activity  and use  th funds  for something  more  promising.

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Dr. K BOSE|  Radiology 156 spec 10Jul 16, 2014
I am confused.. to say the least. Most doctors know what I am talking about, all adults who read papers and watch TV too.

Now Cholesterol is best less than 165,  I have an old British Physiology book that says normal is 290.

BP , cardiologist say below 110 is ideal!

Red wine was great..

Annual Mammos were good.

Tonsillectomy.. a must in all kids. and so on and on

Since I may , I said may have occasional aF, now I have to desist from one scotch in the P.M

Churchill and many other old geezers smoked till death at old age.

I will wait till the next report ten years, from now. I do not have to see, it.





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emmanuel ezeonyebuchi|  Pharmacist 8 prof 8Jul 16, 2014
Moderation is the keyword. Good writeup.

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Dr. Kani Gemici|  Cardiology, General 32 spec 10Jul 16, 2014
perfect philosophy, congratulations.

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Dr. Oben ARI|  Cardiology, General 32 spec 10Jul 16, 2014
Beer is another issue. Type of beer is imporrtant. Alcohol concentration?.

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Dr. H Robert Silverstein|  Cardiology, General 32 spec 10Jul 16, 2014
In 1966 I was told by world famous pathologist Emerich Von Haam that alcohol was toxic to the heart, brain, or liver IN ANY DOSE: I have KNOWN that since then. HRS, MD, FACC

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Dr. Pavel Marcian|  Cardiology, General 32 spec 10Jul 16, 2014
Pavelmarcian@post.cz

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Iouri Banakh|  Pharmacist 8 prof 8Jul 15, 2014
A poison is a poison. AF is only one of many diseases to which it contributes, from dementia to osteoporosis and all the cancers in between.

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Dr. Robert Frater|  Surgery, Cardiothoracic 317 spec 10Jul 15, 2014
50 years ago several insurance companies told me that  life insurance policy holders who took 2 deinks  a day lived longer than those who were teetotallers and those who drank 3 or more drinks a day. With all the enormaousincreases in technology and trial designs we don't seem to knowmuch more than thoseactuaries of half acentury ago

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Stanley levinson|  Other Healthcare Provider 15 prof 15Jul 15, 2014
Interesting. 2 drinks per day is believed to reduce ASCVD; A 14% increase in OR/RR is pretty minimal and certainly open to confounding errors. Greater than any number is always a problem since >3 could be 10 drinks per day which is bad for many organs. Maybe, 3 per day was no worse than 2? If the AF was truly due to alcohol probably the condition would be reverse by drinking less, If the person drank 10 per day, it is unlikely they could stop. Overall, the study does not convince me that occasional to moderate drinking is detrimental

13.09.2014

http://www.medscape.com/viewarticle/828215?src=nl_crb&uac=14249DX

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